The effect of selenium consumption on liver damage index during exercise in a hot environment in rats

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

Department of Exercise Physiology, Faculty of Physical Education and sport sciences, Shahrood University of Technology, Semnan, Iran.

10.22034/ren.2026.144855.1145

Abstract

Aim: Exercise in a hot environment is associated with dysfunction of the liver. The purpose of this study was to investigate the effect of exercise in a hot environment combined with selenium consumption on liver indices in rats.

Method: In this experimental study, 32 male Wistar rats were divided into four groups: control, exercise in a normal environment, exercise in a warm environment, and exercise in a warm environment with selenium supplementation. Exercise was performed for eight weeks in a normal and warm environment. Selenium was administered as an oral supplement at a specific dose. At the end of the period, liver tissue was sampled and ALT and AST gene expression were measured. After confirming the normal distribution of the data, one-way analysis of variance was used to compare the groups and, if necessary, Bonferroni's test was used.

Results: AST gene expression showed a significant increase in the warm environment training groups compared to the control group and a significant decrease in the warm environment + selenium training group, while the difference between the control group and the normal environment training group was not significant. ALT gene expression showed a significant increase in the warm environment training group compared to the control. Also, the warm environment + selenium training group had a decrease in ALT gene expression compared to the warm environment training group.

Conclusion: Training in a hot environment can lead to liver damage, but selenium supplementation plays an effective role in reducing these damages and improving physiological responses.

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History

  • Receive Date: 17 November 2025
  • Revise Date: 26 February 2026
  • Accept Date: 07 March 2026
  • First Publish Date: 07 March 2026

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